[The adaptive response of B cells in culture to the action of cytotoxic agents. I. The stimulation of immunoglobulin synthesis and secretion by myeloma cells, hybridomas and human lymphocytes under the influence of adriamycin and ethidium bromide].

Effects of cytotoxic drugs, doxorubicin (adriamycin) and ethidium bromide, on immunoglobulin production have been studied in B-cell hybridomas, myelomas and human lymphocytes. Doxorubicin, and in a lesser extent ethidium bromide, are shown to enhance immunoglobulin production both in drug-resistant and drug-sensitive cell lines. Enhancement of immunoglobulin production is accompanied with that of the number of antibody forming cells and with immunoglobulin synthesis in these cells.