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[培养中B细胞对细胞毒性制剂作用的适应性反应。II. 免疫球蛋白与阿霉素和溴化乙锭的相互作用]

[The adaptive response of B cells to the action of cytotoxic preparations in culture. II. Immunoglobulin interaction with adriamycin and ethidium bromide].

作者信息

Davtian T K, Meliksetian M B, Aleksanian Iu T, Ignatova T N

出版信息

Tsitologiia. 1993;35(6-7):91-7.

PMID:8266569
Abstract

The binding of adriamycin and ethidium bromide coupled to sepharose beads with intracellular and serum immunoglobulins is detected. These drugs do not bind with Fab and Fc fragments of immunoglobulin. The binding of ethidium bromide to immunoglobulins is competitive. Possible adaptive features of this phenomenon are discussed.

摘要

检测到阿霉素和与琼脂糖珠偶联的溴化乙锭与细胞内及血清免疫球蛋白的结合情况。这些药物不与免疫球蛋白的Fab和Fc片段结合。溴化乙锭与免疫球蛋白的结合具有竞争性。文中讨论了这一现象可能的适应性特征。

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