巴西诺卡菌对利福平的灭活作用。
Inactivation of rifampin by Nocardia brasiliensis.
作者信息
Yazawa K, Mikami Y, Maeda A, Akao M, Morisaki N, Iwasaki S
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
出版信息
Antimicrob Agents Chemother. 1993 Jun;37(6):1313-7. doi: 10.1128/AAC.37.6.1313.
Abstract
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.
摘要
利福平被巴西诺卡氏菌这一病原菌糖基化。从该细菌培养液中分离出的两种糖基化化合物（RIP - 1和RIP - 2）的结构分别被确定为3 - 甲酰基 - 23 -（O - [β - D - 吡喃葡萄糖基]）利福霉素SV和23 -（O - [β - D - 吡喃葡萄糖基]）利福平。这两种化合物对其他革兰氏阳性菌以及诺卡氏菌属均无抗菌活性。
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