致病性诺卡氏菌属对大环内酯类抗生素红霉素、麦迪霉素和罗他霉素的灭活作用
Inactivation of the macrolide antibiotics erythromycin, midecamycin, and rokitamycin by pathogenic Nocardia species.
作者信息
Yazawa K, Mikami Y, Sakamoto T, Ueno Y, Morisaki N, Iwasaki S, Furihata K
机构信息
Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
出版信息
Antimicrob Agents Chemother. 1994 Sep;38(9):2197-9. doi: 10.1128/AAC.38.9.2197.
Abstract
A survey of five Nocardia spp. with respect to susceptibility towards three macrolides (erythromycin, rokitamycin, and midecamycin) showed that the Nocardia spp. have different susceptibility profiles. Most of the resistance was due to the inactivation of the macrolides by phosphorylation, glycosylation, reduction, deacylation, or a combination thereof.
摘要
一项针对五种诺卡氏菌属细菌对三种大环内酯类抗生素（红霉素、罗他霉素和麦迪霉素）敏感性的调查显示，这些诺卡氏菌属细菌具有不同的敏感性特征。大多数耐药性是由于大环内酯类抗生素通过磷酸化、糖基化、还原、脱酰化或这些作用的组合而失活。
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