真菌雅致小克银汉霉对芴的生物转化
Biotransformation of fluorene by the fungus Cunninghamella elegans.
作者信息
Pothuluri J V, Freeman J P, Evans F E, Cerniglia C E
机构信息
National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079.
出版信息
Appl Environ Microbiol. 1993 Jun;59(6):1977-80. doi: 10.1128/aem.59.6.1977-1980.1993.
Abstract
The metabolism of fluorene, a tricyclic aromatic hydrocarbon, by Cunninghamella elegans ATCC 36112 was investigated. Approximately 69% of the [9-14C]fluorene added to cultures was metabolized within 120 h. The major ethyl acetate-soluble metabolites were 9-fluorenone (62%), 9-fluorenol, and 2-hydroxy-9-fluorenone (together, 7.0%). Similarly to bacteria, C. elegans oxidized fluorene at the C-9 position of the five-member ring to form an alcohol and the corresponding ketone. In addition, C. elegans produced the novel metabolite 2-hydroxy-9-fluorenone.
摘要
研究了秀丽隐杆线虫ATCC 36112对三环芳烃芴的代谢。添加到培养物中的[9-¹⁴C]芴约69%在120小时内被代谢。主要的乙酸乙酯可溶代谢物是9-芴酮（62%）、9-芴醇和2-羟基-9-芴酮（总计7.0%）。与细菌类似，秀丽隐杆线虫在五元环的C-9位氧化芴，形成醇和相应的酮。此外，秀丽隐杆线虫产生了新的代谢物2-羟基-9-芴酮。
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