通过高效液相色谱法测定接受长效注射治疗患者的血浆氟奋乃静水平。
Plasma fluphenazine levels measured by high-performance liquid chromatography in patients treated with depot injections.
作者信息
Jouen F, Verité P, André D, Colonna L, Boucly P
机构信息
Centre Hospitalier Spécialisé du Rouvray, Sotteville-lès-Rouen, France.
出版信息
Arzneimittelforschung. 1993 May;43(5):509-11.
Fluphenazine (CAS 69-23-8) concentrations in plasma of schizophrenic patients after oral (fluphenazine hydrochloride, Moditen) or intramuscular (fluphenazine enanthate, Moditen Retard, or fluphenazine decanoate, Modecate) administration of drug were measured by means of high-performance liquid chromatography. The extracted compound was identified by gas chromatography with mass selective detector. Pharmacokinetics of fluphenazine has been studied.
采用高效液相色谱法测定了精神分裂症患者口服（盐酸氟奋乃静，Moditen）或肌肉注射（庚酸氟奋乃静，Moditen Retard，或癸酸氟奋乃静，Modecate）药物后血浆中氟奋乃静（CAS 69-23-8）的浓度。通过带质量选择检测器的气相色谱法对提取的化合物进行鉴定。对氟奋乃静的药代动力学进行了研究。
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