采用自动气相色谱/质量选择检测法测定人血浆中氟奋乃静的皮克级含量。
Picogram level determination of fluphenazine in human plasma by automated gas chromatography/mass selective detection.
作者信息
Jemal M, Ivashkiv E, Both D, Koski R, Cohen A I
机构信息
Squibb Institute for Medical Research, Analytical R&D Department, New Brunswick, New Jersey 08903.
出版信息
Biomed Environ Mass Spectrom. 1987 Dec;14(12):699-704. doi: 10.1002/bms.1200141202.
PMID:3435791
Abstract
An automated capillary column gas chromatography electron-impact mass selective detection method has been developed for the determination of a major tranquilizing agent, fluphenazine. Using a new purification method and incorporating a deuterated internal reference, a limit of quantitation of 50 pg per ml of plasma was obtained.
摘要
已开发出一种自动毛细管柱气相色谱电子轰击质谱选择性检测方法，用于测定一种主要的镇静剂氟奋乃静。采用一种新的纯化方法并加入氘代内标，血浆中氟奋乃静的定量限达到每毫升50皮克。
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