Munoz J J, Cole R L
Infect Immun. 1977 Jan;15(1):84-90. doi: 10.1128/iai.15.1.84-90.1977.
Infection of CFW mice with Trichinella spiralis induced a state of relative unresponsiveness to passive cutaneous anaphylaxis (PCA) induced with hen egg albumin and its corresponding antibodies. The unresponsiveness was to PCA produced either with immunoglobulin G1 (IgG1) or IgE type of antibodies, but was more pronounced with the latter. As few as 25 larvae given by stomach tube 20 days before induced this resistance, although 400 larvae induced a greater resistance. When 400 to 600 larvae were fed to mice, the refractoriness of these mice to PCA was noticed 15 days later. The sera of infected mice had the ability to inhibit mainly PCA induced by IgE. This inhibitory property of sera from infected mice was more pronounced 35 days after infection than 10 months later, when only weak inhibitory activity was detected. Purified rat IgE inhibited the PCA reactions induced in both mice and rats with mouse IgE-type antibody. At high concentrations, evidence of inhibition of the IgG1-induced PCA in mice was also obtained. We believe that the relative unresponsiveness of infected mice is due to an increase in production of IgE which competitively blocks the mast cell sites for other IgE molecules.
用旋毛虫感染CFW小鼠会导致其对用鸡卵白蛋白及其相应抗体诱导的被动皮肤过敏反应（PCA）呈现相对无反应状态。这种无反应状态针对的是用免疫球蛋白G1（IgG1）或IgE型抗体产生的PCA，但对后者更为明显。在诱导前20天经胃管给予低至25条幼虫即可诱导出这种抗性，尽管给予400条幼虫会诱导出更强的抗性。当给小鼠喂食400至600条幼虫时，15天后可观察到这些小鼠对PCA的难治性。感染小鼠的血清主要具有抑制由IgE诱导的PCA的能力。感染小鼠血清的这种抑制特性在感染后35天比10个月后更为明显，10个月后仅检测到微弱的抑制活性。纯化的大鼠IgE可抑制用小鼠IgE型抗体在小鼠和大鼠中诱导的PCA反应。在高浓度时，也获得了抑制小鼠中IgG1诱导的PCA的证据。我们认为，感染小鼠的相对无反应状态是由于IgE产生增加，其竞争性地阻断了其他IgE分子的肥大细胞位点。
