Realmuto G, Begleiter H, Odencrantz J, Porjesz B
Division of Child and Adolescent Psychiatry, University of Minnesota Hospital and Clinic, Minneapolis 55455.
Biol Psychiatry. 1993;33(8-9):594-601. doi: 10.1016/0006-3223(93)90097-w.
The preattentive automatic processing of 63 alcoholics and 27 controls was evaluated with an auditory inattentive event-related oddball paradigm. We examined the mismatch negativity and the N2-P3 complex. Results showed significantly greater amplitude for N2, P3 and the N2-P3 complex for controls but no individual lead (Fz, Cz, Pz) differences by group. A group-by-lead interaction was found for N2 and for the N2-P3 complex. There were no significant latency differences between groups; however, a significant age-by-group interaction effect on latency was greatest at the Cz electrode. Results reflect a possible aberration of automatic processing in alcoholics because of a defect in the mnemonic template necessary to match with an infrequent deviant stimuli. We also found suggestive evidence of a relative weakness of frontal cortical organization in alcoholics. Future studies are suggested that would help clarify these differences in alcoholics.
采用听觉非注意事件相关偏差范式，对63名酗酒者和27名对照者的前注意自动加工进行了评估。我们检测了失匹配负波和N2 - P3复合波。结果显示，对照组的N2、P3和N2 - P3复合波的波幅显著更大，但两组在各个导联（Fz、Cz、Pz）上没有差异。发现N2和N2 - P3复合波存在组×导联交互作用。两组之间在潜伏期上没有显著差异；然而，年龄×组交互作用对潜伏期的显著影响在Cz电极处最为明显。结果反映出酗酒者可能由于与罕见偏差刺激匹配所需的记忆模板存在缺陷，导致自动加工出现异常。我们还发现了酗酒者额叶皮质组织相对薄弱的提示性证据。建议未来开展研究以帮助阐明酗酒者的这些差异。
