Nanko S, Kunugi H, Sasaki T, Fukuda R, Kawate T, Kazamatsuri H
Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.
Biol Psychiatry. 1993;33(8-9):655-8. doi: 10.1016/0006-3223(93)90107-o.
We have undertaken a systematic G-banding survey to find structural chromosomal abnormalities among patients with schizophrenia. Of 120 patients with DSM-III-R schizophrenia, four (3.3%) had a pericentric inversion of chromosome 9 and three (2.5%) had a X/XX mosaicism. The frequency of pericentric inversion of chromosome 9 among patients with schizophrenia was statistically higher than those among newborns and Asian populations. Our results indicate that the pericentric region of chromosome 9 might be one of the potential regions of interest for linkage analysis of schizophrenia.
