无证据表明精神分裂症与9号染色体着丝粒周围区域的DNA标记存在连锁或等位基因关联。

No evidence of linkage or allelic association of schizophrenia with DNA markers at pericentric region of chromosome 9.

作者信息

Nanko S, Fukuda R, Hattori M, Sasaki T, Dai X Y, Gill M, Kuwata S, Shibata Y, Kazamatsuri H

机构信息

Department of Psychiatry, Teikyo University School of Medicine, Tokyo, Japan.

出版信息

Biol Psychiatry. 1994 Nov 1;36(9):589-94. doi: 10.1016/0006-3223(94)90069-8.

DOI:10.1016/0006-3223(94)90069-8

PMID:7833423

Abstract

Based on our previous study suggesting the pericentric region of chromosome 9 as of potential importance in schizophrenia, we have carried out a linkage study between the schizophrenia phenotype and the dinucleotide repeat polymorphisms D9S55, D9S15, and D9S202 in three pedigrees multiply affected with schizophrenia. In addition, we have conducted allelic association studies using 60 patients with schizophrenia and 60 controls with polymorphisms at D9S55 and D9S15 markers. No evidence for linkage or association was found. The results indicate that susceptibility genes for schizophrenia are less likely to be located at the pericentric region of chromosome 9, assuming genetic homogeneity of the pedigrees.

摘要

基于我们之前的研究表明9号染色体的着丝粒周围区域在精神分裂症中具有潜在重要性，我们在三个精神分裂症多发的家系中，对精神分裂症表型与二核苷酸重复多态性D9S55、D9S15和D9S202进行了连锁研究。此外，我们使用60例精神分裂症患者和60例对照，对D9S55和D9S15标记的多态性进行了等位基因关联研究。未发现连锁或关联的证据。结果表明，假设家系具有遗传同质性，精神分裂症的易感基因不太可能位于9号染色体的着丝粒周围区域。