阿尔茨海默病的认知衰退速率与脑电图α波功率相关。

Rate of cognitive decline in Alzheimer's disease is associated with EEG alpha power.

作者信息

Kuskowski M A, Mortimer J A, Morley G K, Malone S M, Okaya A J

机构信息

Geriatric Research, Education and Clinical Center, Minneapolis VA Medical Center, MN 55417.

出版信息

Biol Psychiatry. 1993;33(8-9):659-62. doi: 10.1016/0006-3223(93)90108-p.

DOI:10.1016/0006-3223(93)90108-p

PMID:8329497

Abstract

Fifteen patients with Alzheimer's disease who were initially mildly or moderately impaired were followed for up to 4 years. Scores of the Mini-Mental State Examination (MMSE) were regressed on time of examination (measured at 6-month intervals) to estimate cognitive progression rates in individual patients. A quantitative electroencephalographic (EEG) examination was administered to each patient. Log-absolute EEG power in the alpha bandwidth (8-12 Hz) was found to be correlated with the computed rate of MMSE decline. This association was present for electrode sites across all regions of the scalp and remained significant when the effects of current cognitive severity were partialled out. These data suggest that a quantitative EEG measure (absolute alpha power) is related to the rate of cognitive decline in patients with Alzheimer's disease.

摘要

对15名最初为轻度或中度认知障碍的阿尔茨海默病患者进行了长达4年的随访。对简易精神状态检查表（MMSE）得分与检查时间（每隔6个月测量一次）进行回归分析，以估计个体患者的认知进展率。对每位患者进行了定量脑电图（EEG）检查。发现阿尔法频段（8 - 12赫兹）的对数绝对脑电图功率与MMSE下降的计算速率相关。这种关联在头皮所有区域的电极部位均存在，并且在排除当前认知严重程度的影响后仍具有显著性。这些数据表明，定量脑电图测量（绝对阿尔法功率）与阿尔茨海默病患者的认知衰退速率有关。