Jansen J A, Wolke J G, Swann S, Van der Waerden J P, de Groot K
Department of Oral Function and Prosthetic Dentistry, Laboratory of Biomaterials, Dental School, University of Nijmegen, The Netherlands.
Clin Oral Implants Res. 1993 Mar;4(1):28-34. doi: 10.1034/j.1600-0501.1993.040104.x.
Radiofrequent magnetron sputtering was used to produce calcium phosphate coatings on metal and plastic substrates. Scanning electron microscopy showed that the deposited films had a uniform thickness and a dense columnar structure. Energy-dispersive X-ray analysis, X-ray crystal diffraction and atomic absorption spectrometry demonstrated that the sputtered layer was well-crystallized calcium phosphate ceramic with a Ca/P ratio varying between 1.9 and 2.5. The biocompatibility of the coatings was determined by in vitro and in vivo experiments. It was found that the coatings were biocompatible without any sign of adverse tissue reaction. It was concluded that magnetron sputtering is a promising method for forming a biocompatible ceramic coating onto an implant material. Nevertheless, several problems have to be solved before magnetron sputtering can be used on a routine basis for the production of Ca/P coatings.
采用射频磁控溅射在金属和塑料基底上制备磷酸钙涂层。扫描电子显微镜显示，沉积的薄膜具有均匀的厚度和致密的柱状结构。能量色散X射线分析、X射线晶体衍射和原子吸收光谱表明，溅射层是结晶良好的磷酸钙陶瓷，钙磷比在1.9至2.5之间变化。通过体外和体内实验确定涂层的生物相容性。结果发现涂层具有生物相容性，没有任何不良组织反应的迹象。得出的结论是，磁控溅射是在植入材料上形成生物相容性陶瓷涂层的一种有前途的方法。然而，在磁控溅射能够常规用于生产钙磷涂层之前，还必须解决几个问题。
