Khavari F, Bajpai P K
Department of Biology, University of Dayton, OH 45469-2320.
Biomed Sci Instrum. 1993;29:65-9.
Filling irregular defects caused by trauma or surgery with particulate bone substitutes usually results in migration of the particles from the wound. Coralline blocks have been used successfully to replace diseased bone. Immobilizing coralline particles should be useful in repairing bone defects. Coralline particles of < 45 microns were blended with < 45 microns particles of calcium or zinc sulfate (10%, 20% or 30%). Five gram blocks (20 x 10 mm) of the mixture were pressed at 800 pounds force. Blocks of coral-calcium sulfate were heated at 1000 degrees C and coral-zinc sulfate at 500 degrees C for two hours. The heated blocks were cooled, crushed and sized to < 45 microns particles. Distilled water (200-240 microliters) was added to 210 mg of coralline or coralline-sulfates. A circular rubber mold (10 x 4 mm) was filled with the paste and allowed to harden. Hardness was tested by applying pressure to the tablets at four minute intervals. Consistency equivalent to hardened plaster of Paris was recorded as maximum hardness. Coralline alone did not harden on addition of water. Mixing sulfates with coralline immobilized the particles to maximum hardness within 60 minutes on addition of water. Variation in the amounts of sulfate added (10%-30%) to coralline did not affect the hardening characteristics of the composite.
用颗粒状骨替代物填充由创伤或手术引起的不规则缺损通常会导致颗粒从伤口处迁移。珊瑚块已成功用于替代病变骨骼。固定珊瑚颗粒在修复骨缺损方面应该是有用的。将小于45微米的珊瑚颗粒与小于45微米的硫酸钙或硫酸锌颗粒（10%、20%或30%）混合。将5克该混合物块（20×10毫米）在800磅力下压制。珊瑚 - 硫酸钙块在1000℃加热，珊瑚 - 硫酸锌块在500℃加热两小时。加热后的块冷却、粉碎并筛选成小于45微米的颗粒。向210毫克珊瑚或珊瑚 - 硫酸盐中加入200 - 240微升蒸馏水。将糊状物填充到圆形橡胶模具（10×4毫米）中并使其硬化。每隔四分钟对片剂施加压力来测试硬度。相当于熟石膏硬化后的稠度被记录为最大硬度。仅加入水时，珊瑚本身不会硬化。将硫酸盐与珊瑚混合后，加水后60分钟内颗粒固定至最大硬度。向珊瑚中添加的硫酸盐量（10% - 30%）的变化不影响复合材料的硬化特性。
