Larrabee R A, Fuski M P, Bajpai P K
Department of Biology, University of Dayton, OH 45469-2320.
Biomed Sci Instrum. 1993;29:59-64.
A ferric-calcium-phosphorous oxide ceramic (FECAP) was fabricated for repairing traumatized bone. Seventy-two Sprague-Dawley rats were distributed into three groups: non-operated controls, sham-operated, and FECAP implanted animals. A 4 mm hole was drilled into the diaphysial ridge communicating with the medullary canal in the femurs of sham-operated and experimental animals. In the experimental animals, the hole was packed with 0.25 g of FECAP ceramic particles. Eight animals from each group were sacrificed at 15, 30, and 45 days. Morphological examination and analysis of blood data, body weights, and organ:body weight ratios indicated that FECAP ceramics can be used as non toxic bone substitutes.
