Eisenhauer G, Jermain D M
Department of Psychiatry and Behavioral Sciences, Texas A&M University College of Medicine, Temple.
Ann Pharmacother. 1993 Jun;27(6):725-6. doi: 10.1177/106002809302700610.
To describe a case of tics associated with fluoxetine.
A depressed adolescent was treated with fluoxetine. The patient had not been exposed to any other pharmacologic agents prior to this treatment. Following eight months of fluoxetine therapy the patient developed numerous tics. The movements subsided six months after discontinuation of fluoxetine.
Antidopaminergic effects have been reported in patients treated with fluoxetine. Because fluoxetine is a specific serotonin reuptake inhibitor, one plausible explanation for the extrapyramidal symptoms observed in these patients is that serotonin modulates dopaminergic neurons.
Extrapyramidal symptoms have been reported in patients receiving fluoxetine, although never previously in an adolescent. This case report provides further evidence that fluoxetine may be associated with severe extrapyramidal adverse reactions.
描述一例与氟西汀相关的抽动症病例。
一名患有抑郁症的青少年接受了氟西汀治疗。在此治疗之前，该患者未接触过任何其他药物。经过八个月的氟西汀治疗后，患者出现了大量抽动症状。停用氟西汀六个月后，这些抽动症状消失。
在接受氟西汀治疗的患者中曾有抗多巴胺能效应的报道。由于氟西汀是一种特异性5-羟色胺再摄取抑制剂，对于在这些患者中观察到的锥体外系症状，一个合理的解释是5-羟色胺调节多巴胺能神经元。
在接受氟西汀治疗的患者中曾有锥体外系症状的报道，尽管此前从未在青少年中出现过。本病例报告提供了进一步的证据，表明氟西汀可能与严重的锥体外系不良反应有关。
