Coulter D M, Pillans P I
University of Otago Medical School, Dunedin, New Zealand.
Am J Psychiatry. 1995 Jan;152(1):122-5. doi: 10.1176/ajp.152.1.122.
The authors' goal was to determine whether fluoxetine is associated with extrapyramidal side effects.
They assessed the notifications of extrapyramidal manifestations in patients given fluoxetine in the New Zealand Intensive Medicines Monitoring Programme, a national system that monitored adverse reactions associated with fluoxetine over a 4-year period, and determined whether these adverse reactions were causally related to fluoxetine.
In reports of adverse reactions in 5,555 patients given fluoxetine throughout New Zealand, there were 15 notifications of extrapyramidal events probably or possibly caused by fluoxetine. Fluoxetine was the only psychotropic agent used for seven of the 15 patients; two patients were also taking lithium, four were taking neuroleptics, two were taking tricyclic antidepressants, and one was taking metoclopramide.
The authors conclude that fluoxetine may be associated with extrapyramidal reactions. These may occur with fluoxetine alone or fluoxetine may facilitate the reaction in patients receiving psychotropic medication or dopamine receptor blocking drugs.
作者的目标是确定氟西汀是否与锥体外系副作用相关。
他们在新西兰强化药物监测计划中评估了服用氟西汀患者的锥体外系表现报告，该计划是一个全国性系统，在4年期间监测与氟西汀相关的不良反应，并确定这些不良反应是否与氟西汀存在因果关系。
在新西兰各地5555例服用氟西汀患者的不良反应报告中，有15例锥体外系事件的报告可能或很可能由氟西汀引起。在这15例患者中，有7例仅使用了氟西汀；2例患者还服用了锂盐，4例服用了抗精神病药物，2例服用了三环类抗抑郁药，1例服用了甲氧氯普胺。
作者得出结论，氟西汀可能与锥体外系反应相关。这些反应可能单独由氟西汀引起，或者氟西汀可能会使正在接受精神药物或多巴胺受体阻断药物治疗的患者出现这种反应。
