Gora M L
Division of Pharmacy Practice, University of Kentucky College of Pharmacy and Hospital, Lexington 40536.
Ann Pharmacother. 1993 Jun;27(6):742-50. doi: 10.1177/106002809302700615.
To review the role of transdermal nicotine as an aid to smoking cessation.
A MEDLINE search was performed that included clinical studies published in English involving transdermal nicotine; references used in those articles were screened for additional published information.
Published clinical trials were reviewed with particular emphasis on controlled trials that evaluated safety and efficacy.
Transdermal nicotine therapy has been shown to be a safe and effective pharmacologic aid in a smoking cessation program when used in conjunction with a psychologic or behavior support system. Habitrol, Nicoderm, Nicotrol, and PROSTEP differ in some characteristics (i.e., delivery systems, total nicotine content and amount absorbed, rate of delivery, recommended duration of application); however, the clinical implication of these differences has not been determined.
Transdermal nicotine is effective for patients who are motivated to quit smoking and receive concomitant behavior support.
综述经皮尼古丁在戒烟辅助治疗中的作用。
进行了一项MEDLINE检索，纳入了以英文发表的涉及经皮尼古丁的临床研究；对这些文章中使用的参考文献进行筛选以获取更多已发表的信息。
对已发表的临床试验进行综述，特别强调评估安全性和有效性的对照试验。
经皮尼古丁疗法与心理或行为支持系统联合使用时，已被证明是戒烟计划中一种安全有效的药物辅助手段。哈比托（Habitrol）、尼古丁贴片（Nicoderm）、尼古丁口胶（Nicotrol）和宝仕婷（PROSTEP）在一些特性上有所不同（即给药系统、总尼古丁含量及吸收量、给药速率、推荐使用持续时间）；然而，这些差异的临床意义尚未确定。
经皮尼古丁对有戒烟意愿并获得行为支持的患者有效。
