冷凝集素与肺炎支原体的交叉反应性。
Cold hemagglutinin cross-reactivity with Mycoplasma pneumoniae.
作者信息
Janney F A, Lee L T, Howe C
出版信息
Infect Immun. 1978 Oct;22(1):29-33. doi: 10.1128/iai.22.1.29-33.1978.
Abstract
Convalescent sera from proven cases of infection with Mycoplasma pneumoniae, and rabbit antisera to M. pneumoniae and to human erythrocyte glycoprotein contained cold hemagglutinins which were reactive only for human erythrocytes. Only the human serum cold agglutinins were inhibited by soluble integral glycoproteins derived from human erythrocyte ghosts by treatment with chloroform-methanol. Rabbit antiserum to chloroform-methanol glycoprotein, as well as to M. pneumoniae, fixed complement with either M. pneumoniae or chloroform-methanol glycoprotein antigens. The findings support the hypothesis that the cold agglutinins elicited by M. pneumoniae infection represent a cross-reaction between determinants common to erythrocyte glycoprotein containing I antigen and the membrane of M. pneumoniae.
摘要
来自确诊感染肺炎支原体病例的康复期血清，以及针对肺炎支原体和人红细胞糖蛋白的兔抗血清，均含有仅对人红细胞有反应的冷凝集素。只有人血清冷凝集素能被用氯仿 - 甲醇处理从人红细胞血影衍生的可溶性整合糖蛋白所抑制。兔抗氯仿 - 甲醇糖蛋白血清以及抗肺炎支原体血清，能与肺炎支原体或氯仿 - 甲醇糖蛋白抗原结合补体。这些发现支持了这样一种假说，即肺炎支原体感染引发的冷凝集素代表了含有I抗原的红细胞糖蛋白与肺炎支原体膜共有的决定簇之间的交叉反应。
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