一种新的人甲状腺乳头状癌永久细胞系（GLAG-66）的细胞遗传学特征
Cytogenetic characterization of a new human papillary thyroid carcinoma permanent cell line (GLAG-66).
作者信息
Antonini P, Linares G, Gaillard N, Venuat A M, Schlumberger M, Travagli J P, Caillou B, Berger R, Parmentier C
机构信息
CNRS URA 1158, Laboratoire de Cytogénétique et de Génétique Oncologiques, U66 INSERM, Paris, France.
出版信息
Cancer Genet Cytogenet. 1993 Jun;67(2):117-22. doi: 10.1016/0165-4608(93)90163-g.
A new permanent cell line (GLAG-66) has been established from the metastases of a papillary thyroid carcinoma in a male patient. Herein are reported the cytogenetic characteristics of this new cell line, which is tumorigenic in athymic mice. An aneuploid chromosomal pattern was observed (48 chromosomes) with various chromosomal abnormalities. The karyotype was: 48,XY,der(1)t(9;1;9), +der(8)t(1;8),der(9)t(1;9),der(9)t(1;9), +14. This cell line should prove to be of great value in the study of the biology of human papillary thyroid carcinomas.
已从一名男性患者甲状腺乳头状癌转移灶中建立了一种新的永生细胞系（GLAG - 66）。本文报道了该新细胞系的细胞遗传学特征，它在无胸腺小鼠中具有致瘤性。观察到一种非整倍体染色体模式（48条染色体），伴有各种染色体异常。核型为：48,XY,der(1)t(9;1;9), +der(8)t(1;8),der(9)t(1;9),der(9)t(1;9), +14。该细胞系在人类甲状腺乳头状癌生物学研究中应具有重要价值。
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