候选原癌基因bcl-3编码一种转录共激活因子，该因子通过核因子κB p50同二聚体激活。
The candidate proto-oncogene bcl-3 encodes a transcriptional coactivator that activates through NF-kappa B p50 homodimers.
作者信息
Fujita T, Nolan G P, Liou H C, Scott M L, Baltimore D
机构信息
Rockefeller University, New York, New York 10021.
出版信息
Genes Dev. 1993 Jul;7(7B):1354-63. doi: 10.1101/gad.7.7b.1354.
The candidate proto-oncogene bcl-3 encodes a protein that shares structural features with I kappa B-alpha and other proteins that bind to members of the Rel protein family. Here, we show that in contrast to the inhibitory activity of I kappa B-alpha, the bcl-3 gene product superactivates NF-kappa B p50 homodimer-mediated gene expression both in vivo and in vitro. BCL-3 protein can, as well, selectively associate with p50 homodimers in the presence of DNA containing a kappa B motif. These results strongly suggest that BCL-3 can act as a transcriptional coactivator, acting through DNA-bound p50 homodimers.
候选原癌基因bcl - 3编码一种蛋白质，该蛋白质与IκB -α以及其他与Rel蛋白家族成员结合的蛋白质具有共同的结构特征。在此，我们发现，与IκB -α的抑制活性相反，bcl - 3基因产物在体内和体外均能超激活NF-κB p50同二聚体介导的基因表达。在含有κB基序的DNA存在的情况下，BCL - 3蛋白也能选择性地与p50同二聚体结合。这些结果有力地表明，BCL - 3可以作为一种转录共激活因子，通过与DNA结合的p50同二聚体发挥作用。
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