Hofstetter A G, Kriegmair M
Urologische Klinik, Klinikum Grosshadern, Universität München.
Fortschr Med. 1993 Jun 10;111(16):286-8.
In an open randomized clinical trial, the efficacy of 2.4 mg glycerol trinitrate (GTN) administered in a variety of forms (2 x 1.2 mg capsules; 6 x 0.4 mg puffs of an atomizer; 2.4 ml of an 0.1% infusion solution) in comparison with 20 mg of butylscopolamine bromide i.v. (BSB) in 80 patients suffering from acute ureteral colic.
Some 30 minutes following medication, the effect was adjudged by the physician to be good (no pain) moderate (some pain still present) or non-existent (alternative treatment within 30 minutes).
GTN was effective in 40% of the cases, BSB in 26.3%. A moderate effect was seen in 46.7% and 62.3%, respectively, while no response was elicited in 13.3 and 10.5%, respectively. In addition, recurrence within 24 hours, blood pressure, pulse rate and laboratory tests were recorded. Side effects occurred in 13 patients (12 in the GTN and 1 in the BSB group), but, with one exception (GTN i.v.), were all mild in nature.
在一项开放性随机临床试验中，将2.4毫克硝酸甘油（GTN）以多种形式给药（2粒1.2毫克胶囊；6喷0.4毫克雾化器喷雾；2.4毫升0.1%输注溶液），并与20毫克静脉注射丁溴东莨菪碱（BSB）对比，研究对象为80例急性输尿管绞痛患者。
用药后约30分钟，医生判定效果为良好（无疼痛）、中等（仍有一些疼痛）或无效（30分钟内接受替代治疗）。
GTN在40%的病例中有效，BSB在26.3%的病例中有效。分别有46.7%和62.3%的病例有中等效果，而分别有13.3%和10.5%的病例无反应。此外，记录了24小时内的复发情况、血压、脉搏率和实验室检查结果。13例患者出现副作用（GTN组12例，BSB组1例），但除1例（静脉注射GTN）外，均为轻度副作用。
