Heyden G, Kindblom L G, Nielsen J M
J Bone Joint Surg Am. 1977 Jan;59(1):57-61.
The case histories of three patients, a man and two boys, with disappearing bone disease are reported. The clinical, roentgenographic, and histopathological features are described in detail. Histologically, in the early stages of the disease, the vanishing bone is replaced by numerous wide engorged capillaries. Eventually the bone is replaced by dense fibrous tissue. All three patients were treated by radiotherapy. Histochemical studies performed in one case revealed strong acid phosphatase and leucine aminopeptidase activities in perivascular mononuclear cells (possibly pericytes), suggesting that these cells took part in the bone resorption.
报告了3例患有骨质溶解症患者的病历，其中1名男性和2名男孩。详细描述了其临床、放射学和组织病理学特征。组织学上，在疾病早期，消失的骨组织被大量扩张充血的毛细血管所取代。最终，骨组织被致密的纤维组织所替代。所有3例患者均接受了放射治疗。对其中1例患者进行的组织化学研究显示，血管周围单核细胞（可能是周细胞）中存在强酸性磷酸酶和亮氨酸氨肽酶活性，提示这些细胞参与了骨吸收过程。
