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[胸腺、下丘脑 - 垂体区域及性腺照射对小鼠移植性Lewis癌生长的影响]

[The effect of irradiation of the thymus, the hypothalamo-hypophyseal area and the gonads on the growth of a transplanted Lewis carcinoma in mice].

作者信息

Savina N P, Iarilin A A, Konopliannikov A G

出版信息

Radiobiologiia. 1993 May-Jun;33(3):329-36.

PMID:8332709
Abstract

Irradiation of thymus with doses of 0.5 to 10 Gy and gonads with 10 Gy does not influence the growth of the tumor transplanted 10 days after irradiation and accelerates the growth of the tumor transplanted 11-12 months after exposure. Irradiation of hypophysis and hypothalamus with doses of 1 and 10 Gy accelerates the growth of the tumor transplanted 10 days and 11-12 months after exposure. In the latter case the effect was more pronounced. When thymus, hypothalamus and hypophysis were exposed simultaneously the effect was analogous to that observed after isolated exposure of hypothalamus/hypophysis but somewhat more pronounced. Irradiation of hypothalamus/hypophysis caused earlier and severer changes in the anti-tumor resistance than the exposure of thymus and gonads did.

摘要

用0.5至10戈瑞的剂量照射胸腺以及用10戈瑞的剂量照射性腺,对照射10天后移植的肿瘤生长没有影响,但会加速照射11至12个月后移植的肿瘤生长。用1和10戈瑞的剂量照射垂体和下丘脑,会加速照射10天以及11至12个月后移植的肿瘤生长。在后一种情况下,效果更为明显。当同时照射胸腺、下丘脑和垂体时,效果类似于单独照射下丘脑/垂体后观察到的效果,但更为明显一些。与照射胸腺和性腺相比,照射下丘脑/垂体会导致抗肿瘤抵抗力出现更早、更严重的变化。

相似文献

1
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Radiobiologiia. 1993 May-Jun;33(3):329-36.
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