Taccagni G, Sambade C, Nesland J, Terreni M R, Sobrinho-Simões M
Department of Pathology, University of Milan, San Raffaele Hospital, Italy.
Virchows Arch A Pathol Anat Histopathol. 1993;422(6):491-7. doi: 10.1007/BF01606459.
We describe three cases of solitary fibrous tumour (SFT) arising from thyroid stroma. Grossly, the tumours were clearly delimited but only partly encapsulated. The following histomorphological growth patterns were observed: bundles of cells in storiform configuration; non-structured bundles; prevalence of fibrous matrix; highly cellular, non-structured; prevalence of loose, non-structured extracellular substance; cellular proliferation and vascular spaces in a haemangiopericytic configuration and a lipomatous component. Immunohistochemical investigation demonstrated intense, diffuse vimentin positivity and focal, less intense actin positivity in all three cases. At electron microscopy we observed a primitive cell of mesenchymal type, with cytoplasm poor in organelles and rich in filaments; this cell sometimes presented differentiation characteristics. SFT is at present the most correct term for the lesions presented here despite some morphological characteristics which differ from cases reported in the literature.
我们描述了3例起源于甲状腺间质的孤立性纤维瘤（SFT）。大体上，肿瘤边界清晰，但仅部分有包膜。观察到以下组织形态学生长模式：呈席纹状排列的细胞束；无结构的束状；纤维基质为主；细胞丰富、无结构；疏松、无结构的细胞外物质为主；呈血管外皮细胞瘤样结构的细胞增殖和血管间隙以及脂肪成分。免疫组织化学研究显示，所有3例均有强烈弥漫性波形蛋白阳性以及局灶性、较弱的肌动蛋白阳性。电镜下我们观察到间充质型原始细胞，其细胞质细胞器较少而富含细丝；该细胞有时呈现分化特征。尽管此处所呈现病变的一些形态学特征与文献报道的病例有所不同，但SFT是目前对此处病变最恰当的术语。
