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囊性纤维化患者血清白细胞介素-1α和可溶性白细胞介素-2受体浓度

Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosis.

作者信息

Greally P, Hussain M J, Vergani D, Price J F

机构信息

Department of Child Health, King's College Hospital, London.

出版信息

Arch Dis Child. 1993 Jun;68(6):785-7. doi: 10.1136/adc.68.6.785.

DOI:10.1136/adc.68.6.785
PMID:8333775
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1029377/
Abstract

Interleukin (IL)-1 and IL-2 may participate in the systemic inflammatory response and hypergammaglobulinaemia observed in patients with cystic fibrosis. Thirty seven patients with cystic fibrosis were compared with 25 normal controls. High IgG and IgM concentrations were associated with more severe pulmonary disease. IL-1 alpha and soluble IL-2 receptor concentrations were higher in the cystic fibrosis group than in the controls and also correlated with concentrations of IgG and IgM. These results suggest that these cytokines may contribute to enhanced immunoglobulin synthesis and silent inflammatory activity in clinically stable patients with cystic fibrosis.

摘要

白细胞介素（IL）-1和IL-2可能参与了囊性纤维化患者出现的全身炎症反应和高丙种球蛋白血症。将37例囊性纤维化患者与25名正常对照者进行了比较。高IgG和IgM浓度与更严重的肺部疾病相关。囊性纤维化组的IL-1α和可溶性IL-2受体浓度高于对照组，且与IgG和IgM浓度相关。这些结果表明，这些细胞因子可能有助于临床稳定的囊性纤维化患者增强免疫球蛋白合成和隐匿性炎症活动。

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本文引用的文献

1
Progression of cystic fibrosis lung disease as a function of serum immunoglobulin G levels: a 5-year longitudinal study.囊性纤维化肺病进展与血清免疫球蛋白G水平的关系：一项5年纵向研究
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Raised serum soluble interleukin-2 receptor concentrations in cystic fibrosis patients with and without evidence of lung disease.患有和未患有肺部疾病证据的囊性纤维化患者血清可溶性白细胞介素-2受体浓度升高。
Arch Dis Child. 1992 Apr;67(4):479-81. doi: 10.1136/adc.67.4.479.