Vázquez Cordero C, Sánchez Obregón M, Molinuevo Alvaro J, Larrea Rementería F, Vitoria Cormenzana J C, Sojo Aguirre A
Sección de Neumología Pediátrica, Hospital Infantil de Cruces, Baracaldo, Vizcaya.
An Esp Pediatr. 1988 Apr;28(4):321-4.
IgG serum levels were measured in 25 patients with cystic fibrosis aged 1 to 19 years and in 4 additional patients deceased over the last 4 years. Levels were correlated with a number of parameters. Twelve patients (group A) had raised IgG levels, and 17 (group B) normal or low levels. Age between groups did not differ. Patients in group A had lower Shwachman score (p less than 0.001), worse Chrispin and Norman radiologic score (p less than 0.05), lower weight (p less than 0.001) and height (p less than 0.05) and lower FVC (p less than 0.05), and FEV1 (p less than 0.01). Raised levels were associated with increased number of serum precipitins against Pseudomonas aeruginosa but not against Staphylococcus aureus. Raised IgG levels might be secondary to heavier bronchial infection, but there is growing evidence that immunologic response in cystic fibrosis may worsen the course of the disease.
对25名年龄在1至19岁的囊性纤维化患者以及另外4名在过去4年中死亡的患者测定了血清IgG水平。这些水平与一些参数相关。12名患者（A组）的IgG水平升高，17名患者（B组）的水平正常或较低。两组之间的年龄无差异。A组患者的Shwachman评分较低（p<0.001），Chrispin和Norman放射学评分较差（p<0.05），体重（p<0.001）和身高（p<0.05）较低，FVC（p<0.05）和FEV1（p<0.01）也较低。IgG水平升高与抗铜绿假单胞菌血清沉淀素数量增加有关，但与抗金黄色葡萄球菌无关。IgG水平升高可能继发于较重的支气管感染，但越来越多的证据表明，囊性纤维化中的免疫反应可能会使疾病进程恶化。
