Koenig J Q, Dumler K, Rebolledo V, Williams P V, Pierson W E
Department of Environmental Health, University of Washington, Seattle.
Arch Environ Health. 1993 May-Jun;48(3):171-5. doi: 10.1080/00039896.1993.9940816.
The objective of this study was two-fold: (1) to investigate the response of asthmatic subjects who were 60 to 75 y of age to inhaled sulfuric acid, and (2) to compare that response to findings from healthy subjects in the same age group. Nine subjects who had asthma and eight healthy subjects participated. Each subject was exposed to clean air, an inert ammonium sulfate aerosol, or 70 micrograms/m3 sulfuric acid during a 40-min exposure period composed of 30 min at rest and 10 min of light exercise on a treadmill. The sulfuric acid was delivered twice, one preceded by a lemonade drink to neutralize oral concentrations of ammonia. Exposures were separated by at least 1 wk. Oral ammonia levels and pulmonary function parameters (forced expiratory volume in one second, forced vital capacity, and total respiratory resistance) were measured before and after each exposure. None of the functional parameters in either group showed significant changes. However, total respiratory resistance changes from baseline after sulfuric acid exposure were significantly higher (+16%) in the asthmatic subjects, compared with the healthy subjects (-6%). These data suggest that older subjects are not at increased risk for adverse respiratory effects from inhalation of sulfuric acid by virtue of age alone, and older subjects with asthma are slightly more vulnerable than are their healthy peers.
（1）调查60至75岁哮喘患者对吸入硫酸的反应，（2）将该反应与同年龄组健康受试者的结果进行比较。九名哮喘患者和八名健康受试者参与了研究。在40分钟的暴露期内，每位受试者分别暴露于清洁空气、惰性硫酸铵气溶胶或70微克/立方米的硫酸中，该暴露期包括30分钟的休息和在跑步机上10分钟的轻度运动。硫酸分两次输送，一次在饮用柠檬水以中和口腔内氨浓度之后。暴露之间至少间隔1周。在每次暴露前后测量口腔氨水平和肺功能参数（一秒用力呼气量、用力肺活量和总呼吸阻力）。两组的功能参数均未显示出显著变化。然而，与健康受试者（-6%）相比，哮喘患者在硫酸暴露后总呼吸阻力相对于基线的变化显著更高（+16%）。这些数据表明，仅因年龄因素，老年受试者吸入硫酸后出现不良呼吸影响的风险并未增加，且老年哮喘患者比健康同龄人稍显更易受影响。
