Imamura M, Martin W J
J Immunogenet. 1980 Feb;7(1):31-7. doi: 10.1111/j.1744-313x.1980.tb00705.x.
The K region of the H-2 major histocompatibility complex (MHC) of mice of H-2Kk haplotype codes for two distinct alloantigens. One of these alloantigens, designated k-common, is expressed by C3HfB/HeN mice (C3Hf). The other alloantigen, designated k-unique, is not expressed by C3Hf mice. The H-2 haplotype of C3Hf mice has been classified as kv1 and the variant antigen distinguishing this strain from mice of H-2Kk haplotype has been designated kv1-unique. Several transplacentally-induced lung tumours of C3Hf mice express the k-unique, rather than the expected kv1-unique, antigen. The immunogenicity of the k-unique antigen on C3Hf-derived lung tumours varies with different tumours. In particular, the capacity of the k-unique antigen to induce radioresistant immunity in C3Hf mice appears to be lost on long term cultured tumour cells even though the tumour remains susceptible to in vivo immune responses directed against the k-unique antigen. Alterations in expression and in immunogenicity of unique H-2-coded antigens may dictate the nature and efficacy of immune surveillance of autochthanous tumours.
H-2Kk单倍型小鼠的H-2主要组织相容性复合体（MHC）的K区域编码两种不同的同种异体抗原。其中一种同种异体抗原，称为k-共同抗原，由C3HfB/HeN小鼠（C3Hf）表达。另一种同种异体抗原，称为k-独特抗原，C3Hf小鼠不表达。C3Hf小鼠的H-2单倍型已被分类为kv1，区分该品系与H-2Kk单倍型小鼠的变异抗原已被指定为kv1-独特抗原。C3Hf小鼠的几种经胎盘诱导的肺肿瘤表达k-独特抗原，而不是预期的kv1-独特抗原。C3Hf来源的肺肿瘤上k-独特抗原的免疫原性因不同肿瘤而异。特别是，k-独特抗原在C3Hf小鼠中诱导抗辐射免疫的能力在长期培养的肿瘤细胞上似乎丧失了，尽管肿瘤仍然易受针对k-独特抗原的体内免疫反应的影响。独特的H-2编码抗原的表达和免疫原性的改变可能决定了对自身肿瘤免疫监视的性质和效果。
