Kaufman M J, Madras B K
Department of Psychiatry, Harvard Medical School, Southborough, MA.
Brain Res. 1993 May 21;611(2):322-5. doi: 10.1016/0006-8993(93)90519-s.
The distribution of a tracer dose of the dopamine transport probe [3H]CFT ([3H]WIN 35,428; 2.5 nmol/kg) in brain was examined 90 min following intravenous administration to a mature (8 years, approximately) and an aged (> 20 years) squirrel (Saimiri sciureus) monkey. Ex vivo autoradiography revealed [3H]CFT labeling predominantly in dopamine-rich regions. The high striatum:cerebellum ratio, 5.6, compares favorably with other markers for dopamine systems. Ligand accumulation in striatum was substantially lower in the aged monkey compared with the younger adult monkey. The present findings support the use of the cocaine congener CFT for monitoring the dopamine transporter on dopamine nerve terminals by PET (positron emission tomography) imaging.
在向一只成熟（约8岁）和一只老年（>20岁）松鼠猴（松鼠猴属）静脉注射多巴胺转运体探针[3H]CFT（[3H]WIN 35,428；2.5 nmol/kg）的示踪剂量后90分钟，检测了其在脑中的分布。离体放射自显影显示[3H]CFT标记主要位于富含多巴胺的区域。纹状体与小脑的高比值（5.6）与多巴胺系统的其他标记物相比具有优势。与年轻成年猴相比，老年猴纹状体中的配体积累显著更低。本研究结果支持使用可卡因同系物CFT通过正电子发射断层扫描（PET）成像来监测多巴胺神经末梢上的多巴胺转运体。
