结肠镜监测可降低溃疡性结肠炎患者结直肠癌的死亡率。
Colonoscopic surveillance reduces mortality from colorectal cancer in ulcerative colitis.
作者信息
Choi P M, Nugent F W, Schoetz D J, Silverman M L, Haggitt R C
机构信息
Department of Gastroenterology, Lahey Clinic Medical Center, Burlington, Massachusetts.
出版信息
Gastroenterology. 1993 Aug;105(2):418-24. doi: 10.1016/0016-5085(93)90715-o.
BACKGROUND
To control the increased risk of colorectal carcinoma in patients with long-standing ulcerative colitis, surveillance colonoscopy is widely recommended.
METHODS
To assess the role of colonoscopic surveillance in affecting colorectal carcinoma-related mortality, an outcome analysis was performed.
RESULTS
Among the total of 41 patients who developed carcinoma associated with ulcerative colitis, 19 patients were under colonoscopic surveillance and 22 patients were not. Carcinoma was detected at a significantly earlier Dukes' stage in the surveillance group (P = 0.039). Four patients in the surveillance group died, compared with 11 patients in the no-surveillance group. The 5-year survival rate was 77.2% for the surveillance group and 36.3% for the no-surveillance group (P = 0.026).
CONCLUSIONS
These results suggest that colonoscopic surveillance reduces colorectal carcinoma-related mortality by allowing the detection of carcinoma at an earlier Dukes' stage.
背景
为控制长期溃疡性结肠炎患者结直肠癌风险的增加，广泛推荐进行监测性结肠镜检查。
方法
为评估结肠镜监测在影响结直肠癌相关死亡率方面的作用，进行了一项结局分析。
结果
在总共41例发生与溃疡性结肠炎相关癌症的患者中，19例接受了结肠镜监测，22例未接受监测。监测组癌症在明显更早的杜克分期被检测到（P = 0.039）。监测组有4例患者死亡，未监测组有11例患者死亡。监测组的5年生存率为77.2%，未监测组为36.3%（P = 0.026）。
结论
这些结果表明，结肠镜监测通过使癌症在更早的杜克分期被检测到，降低了结直肠癌相关死亡率。
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