Markianos E S, Rüther E
J Neural Transm. 1977;40(1):21-5. doi: 10.1007/BF01250277.
Serum dopamine-beta-hydroxylase activities of a group of 16 parkinsonian patients under L-Dopa plus decarboxylase inhibitor showed a distribution with a drift towards higher activities compared to a group of normals of the same age range. Acute doses of L-Dopa failed to cause any change in the serum enzyme activities as well as in the serum concentration of 3-methoxy-4-hydroxyphenylethylene glycol, in parkinsonian patients and in normals. The data support the idea of a limited influence of L-Dopa on the noradrenaline synthesis and release in parkinsonism.
一组16名接受左旋多巴加脱羧酶抑制剂治疗的帕金森病患者的血清多巴胺-β-羟化酶活性显示，与同一年龄范围的正常人群相比，其分布向更高活性偏移。在帕金森病患者和正常人中，急性剂量的左旋多巴未能引起血清酶活性以及3-甲氧基-4-羟基苯乙二醇血清浓度的任何变化。这些数据支持左旋多巴对帕金森病中去甲肾上腺素合成和释放影响有限的观点。
