Ackermann H, Ziegler W, Petersen D
Neurologische Universitätsklinik, Tübingen, Germany.
J Neurol. 1993 Jun;240(6):357-62. doi: 10.1007/BF00839967.
A patient suffering from bilateral thalamic infarction in the region supplied by the paramedian arteries sparing the internal capsules underwent acoustic analysis of sentence utterances. The results were compared with the findings obtained in parkinsonian subjects, in patients with upper motor neuron lesions, and in normal subjects. Acoustic measurements revealed increased pitch, monotonous speech, rough voice quality, and normal speech tempo concomitant with articulatory impreciseness in terms of incomplete closure productions. This constellation resembled parkinsonian dysarthria. Damage to the thalamic projection area of the pallidal efferents, therefore, seems to be the most probable cause of the patient's speech disorders. In parkinsonian subjects stereotactical lesions of this structure ameliorate rigor, but not akinesia. Thus, our patient's speech deficits, and by analogy the corresponding parkinsonian dysarthric disturbances, may be considered akinetic signs.
一名双侧丘脑梗死患者，梗死区域由旁正中动脉供血，内囊未受累，对其语句进行了声学分析。将结果与帕金森病患者、上运动神经元损伤患者及正常受试者的结果进行比较。声学测量显示，音高增加、语音单调、音质粗糙、语速正常，同时在发音方面存在不精确性，表现为发音不完全闭合。这种情况类似于帕金森病构音障碍。因此，苍白球传出纤维丘脑投射区受损似乎是该患者言语障碍的最可能原因。在帕金森病患者中，对该结构进行立体定向损伤可改善僵直，但不能改善运动不能。因此，我们患者的言语缺陷，以及与之类似的帕金森病构音障碍，可被视为运动不能的体征。
