Yoshida M, Hoshi H
J Nutr. 1977 Jan;107(1):35-41. doi: 10.1093/jn/107.1.35.
The protective effect of supplemental selenium, methionine, ascorbic acid, menaquinone and five antioxidants against encephalomalacia of chicks fed a diet containing dilauryl succinate was examined. Diauryl succinate induces vitamin E deficiency signs such as fragility of the erythrocytes and encephalomalacia. Supplementation of selenium and methionine with or without simultaneous supplementation of a low level of dl-alpha-tocopheryl acetate had little effect on preventing encephalomalacia. The preventive effect of ascorbic acid, methylene blue, ethoyquine, 2,6-ditertiary-butyl-p-cresol and butylated hydroxyanisole was roughly in proportion to their dietary level, and a high level of any of them could almost completely protect the chicks from encephalomalacia, while diphenyl-p-phenylenediamine was not as effective and the effect was not proportional to the dose. Menaquinone had little effect. No difference was observed in the plasma tocopherol levels and peroxide levels in the adipose tissueof the chick fed eith er dilauryl succinate or cornstarch. The effect of dilauryl succinate appears to be independent of peroxides generated in the chick.
研究了补充硒、蛋氨酸、抗坏血酸、甲萘醌和五种抗氧化剂对饲喂含琥珀酸二月桂酯日粮的雏鸡脑软化症的保护作用。琥珀酸二月桂酯会引发维生素E缺乏症，如红细胞脆性增加和脑软化。单独补充硒和蛋氨酸，或同时补充低水平的dl-α-生育酚醋酸酯，对预防脑软化症几乎没有效果。抗坏血酸、亚甲蓝、乙氧喹、2,6-二叔丁基对甲酚和丁基化羟基茴香醚的预防效果大致与日粮水平成正比，其中任何一种高剂量时几乎都能完全保护雏鸡免受脑软化症侵害，而二苯胺对苯二胺效果不佳，且效果与剂量不成正比。甲萘醌几乎没有效果。饲喂琥珀酸二月桂酯或玉米淀粉的雏鸡，其血浆生育酚水平和脂肪组织中的过氧化物水平没有差异。琥珀酸二月桂酯的作用似乎与雏鸡体内产生的过氧化物无关。
