Ikumo H
J Nutr. 1980 Oct;110(10):2051-7. doi: 10.1093/jn/110.10.2051.
In order to elucidate the mechanism of dilauryl succinate-induced vitamin E deficiency in vivo in chicks, I conducted experiments to study the effect of the metabolites of dilauryl succinate in chicks on hemolysis and the liver mitochondrial lysis, while neither lauryl alcohol nor succinic acid induced mitochondrial lysis in vitro in chicks. These were monolauryl succinate, lauryl alcohol and succinic acid. Monolauryl succinate induced both hemolysis and mitochondrial lysis at the same concentration as that of monolauryl succinate. At the concentration of 40 times that of monolauryl succinate, lauryl alcohol induced hemolysis but succinic acid did not. Neither alpha-tocopherol, selenium nor combination of both exerted preventive effects on the reactions of monolauryl succinate or lauryl alcohol. Monolauryl succinate-induced mitochondrial lysis was not accompanied by lipid peroxidation. The observations were consistent with those in Tween 20-induced hemolysis and mitochondrial lysis, but not with those in hydrogen peroxide-induced hemolysis or with those in glutathione-induced mitochondrial lysis. It was suggested that dilauryl succinate-induced vitamin E deficiencies in vivo in chicks are mainly due to the surface activity, which is not relevant to peroxide formation, of monolauryl succinate and partly to that of lauryl alcohol.
为了阐明丁二酸二月桂酯在雏鸡体内诱发维生素E缺乏的机制，我进行了实验，研究丁二酸二月桂酯的代谢产物对雏鸡溶血和肝线粒体裂解的影响，而月桂醇和琥珀酸在体外均未诱发雏鸡线粒体裂解。这些物质是单月桂基琥珀酸酯、月桂醇和琥珀酸。单月桂基琥珀酸酯在与单月桂基琥珀酸酯相同的浓度下既诱发溶血又诱发线粒体裂解。在单月桂基琥珀酸酯浓度40倍时，月桂醇诱发溶血而琥珀酸未诱发。α-生育酚、硒或二者的组合均未对单月桂基琥珀酸酯或月桂醇的反应产生预防作用。单月桂基琥珀酸酯诱发的线粒体裂解未伴随脂质过氧化。这些观察结果与吐温20诱发的溶血和线粒体裂解中的观察结果一致，但与过氧化氢诱发的溶血或谷胱甘肽诱发的线粒体裂解中的观察结果不一致。提示丁二酸二月桂酯在雏鸡体内诱发维生素E缺乏主要是由于单月桂基琥珀酸酯的表面活性（与过氧化物形成无关），部分是由于月桂醇的表面活性。
