McGinity J W, Lach J L
J Pharm Sci. 1977 Jan;66(1):63-6. doi: 10.1002/jps.2600660115.
Urinary recovery studies showed that montmorillonite significantly affects the initial therapeutic levels of amphetamine sulfate. The combination of a 1:20 drug-montmorillonite complex with pure drug in a 1:1 ratio, based on amphetamine content, resulted in recovery profiles resembling those obtained from prolonged-release dosage forms. The 1:20 complex, pure drug, and combination formulations showed comparable bioavailability after 48 hr.
尿液回收研究表明，蒙脱石对硫酸苯丙胺的初始治疗水平有显著影响。基于苯丙胺含量，将1:20的药物 - 蒙脱石复合物与纯药物以1:1的比例混合，其回收曲线类似于从缓释剂型获得的曲线。48小时后，1:20复合物、纯药物和组合制剂显示出相当的生物利用度。
