Rall H J, van Niekerk W A, Engelbrecht B H, van Schalkwyk D J
J Reprod Med. 1977 Feb;18(2):55-60.
Three-month (150 mg) and six-month (450 mg) contraceptive regimens of medroxyprogesterone acetate (DMPA) as an intramuscular depot injection are compared in this paper. A total of 19,875 women participated in the study, accounting for 220,530 woman-months of use. A Pearl index of 0.1069 for the three-month regimen was significantly lower than for the six-month group, where the index was 0.4943 (p less than 0.01). Side effects were limited insofar as personal reasons and loss to follow-up were the most important single category for discontinuation of this contraceptive method. No thrombotic incidents occurred. It is concluded that both contraceptive regimens of DMPA appear to be acceptable with regard to use-effectiveness, patient acceptance and prevalence of side effects.
本文比较了醋酸甲羟孕酮（DMPA）作为肌肉注射长效避孕针剂的三个月（150毫克）和六个月（450毫克）避孕方案。共有19875名女性参与了该研究，累计使用时长为220530妇女月。三个月方案的 Pearl 指数为0.1069，显著低于六个月组的0.4943（p<0.01）。副作用有限，个人原因和失访是停用这种避孕方法的最重要单一类别。未发生血栓事件。结论是，DMPA 的两种避孕方案在使用效果、患者接受度和副作用发生率方面似乎都是可以接受的。
