Sataloff R T, Wilborn A, Prestipino A, Hawkshaw M, Heuer R J, Cohn J
Department of Medicine, Thomas Jefferson University, Philadelphia, PA 19103.
Am J Otolaryngol. 1993 May-Jun;14(3):199-205. doi: 10.1016/0196-0709(93)90030-b.
Laryngeal histoplasmosis was first described in 1952. Since then, fewer than 100 cases had been reported. This dimorphic fungus is endemic in the Mississippi and Ohio River Valleys. The yeast phase is responsible for human infection.
We report a 44-year-old woman who developed laryngitis. The markedly abnormal larynx, which could have been mistaken for papillomatosis, was biopsied, at which time the diagnosis of histoplasmosis was confirmed. Treatment with oral ketoconazole was instituted.
Objective voice assessment showed abnormalities of maximum phonation time, speaking fundamental frequency, perturbation, percent voicing, mean flow rate, and spectral pattern. Subsequent to antifungal therapy, objective measures were improved.
This represents the first case of laryngeal histoplasmosis in which response to therapy is documented by objective vocal assessment.
喉组织胞浆菌病于1952年首次被描述。自那时起，报告的病例少于100例。这种双相真菌在密西西比河和俄亥俄河流域为地方病。酵母阶段是人类感染的原因。
我们报告一名44岁患喉炎的女性。对明显异常的喉部（可能被误诊为乳头状瘤病）进行活检，此时确诊为组织胞浆菌病。开始口服酮康唑治疗。
客观嗓音评估显示最大发声时间、说话基频、扰动、发声百分比、平均流速和频谱模式存在异常。抗真菌治疗后，客观指标有所改善。
这是第一例通过客观嗓音评估记录治疗反应的喉组织胞浆菌病病例。
