Reuter G, Zilles K
Hearing Research Laboratories, University of Tübingen, Germany.
Ann Anat. 1993 Jun;175(3):243-51. doi: 10.1016/s0940-9602(11)80010-5.
The development of the nervous system can be modified by the application of transmitter agonist or antagonists. Therefore, the growth of the retina in chicken embryos was studied after injection of the excitatory amino acid, kainate, during the second half of the pre-hatching period. Quantitative anatomical and biochemical investigations were undertaken. In the kainate treated animals the volume of the retina and its different layers was seen to exceed significantly those of control retinas from the 14th ontogenetic day onwards. This was accompanied by a total increase in cell number as well as DNA content on the 18th day of ontogenesis, though the mitotic activity during this period was comparable to that in the control group, and signs of degenerative processes ("rosettes") were found. Therefore, we conclude that the excitatory amino acid, kainate, reduces the naturally occurring cell death in the embryonic retina.
神经系统的发育可通过应用递质激动剂或拮抗剂来改变。因此，在孵化前期的后半期给鸡胚注射兴奋性氨基酸红藻氨酸后，对其视网膜的生长进行了研究。进行了定量解剖学和生物化学研究。在红藻氨酸处理的动物中，从个体发育的第14天起，视网膜及其不同层的体积明显超过对照视网膜。这伴随着个体发育第18天细胞数量和DNA含量的总体增加，尽管在此期间的有丝分裂活性与对照组相当，并且发现了退行性过程（“玫瑰花结”）的迹象。因此，我们得出结论，兴奋性氨基酸红藻氨酸可减少胚胎视网膜中自然发生的细胞死亡。
