Gilles F H, Winston K, Fulchiero A, Leviton A
J Natl Cancer Inst. 1977 Feb;58(2):175-81. doi: 10.1093/jnci/58.2.175.
Variation existed in the recognition of histologic features commonly used in the evaluation of cerebellar gliomas of childhood. Some histologic features (e.g., perivascular pseudorosettes, leptomeningeal deposits, and calcification) were more reliably observed than were others (e.g., Rosenthal fibers, cell density, and hypervascularity). Knowledge of which features tend to have greater observational variation may lead to improved definitions, less reliance of these features in clinical decisions, further studies of the potential sources of the variation, and guidelines for minimizing observational variation.
在儿童小脑胶质瘤评估中常用的组织学特征识别方面存在差异。一些组织学特征（如血管周围假菊形团、软脑膜沉积物和钙化）比其他特征（如罗森塔尔纤维、细胞密度和血管增多）更易于可靠观察。了解哪些特征往往存在较大的观察差异，可能会带来更完善的定义，减少临床决策中对这些特征的依赖，进一步研究差异的潜在来源，以及制定最小化观察差异的指南。
