Fulchiero A, Winston K, Leviton A, Gilles F H
J Natl Cancer Inst. 1977 Apr;58(4):839-43. doi: 10.1093/jnci/58.4.839.
Temporal changes in the histologic composition of cerebellar gliomas were examined in a population of 132 children operated on between 1927 and 1968 at The Children's Hospital Medical Center of Boston. Linear trends with time were examined for clinical features, histologic features, and tumor types. We found evidence of an increasing occurrence of glioma A and its associated features during the 41-year study period. This tumor type is associated with a good prognosis and is histologically well defined. Glioma B, a tumor type associated with a poor prognosis, was relatively stable with respect to time and, therefore, differed markedly from glioma A. Foci of oligodendroglia, a glioma A feature, clustered by year of surgery within a relatively short time span. This feature had a survival rate and a male sex proportion quite different from those of the other histologic features investigated.
在1927年至1968年间于波士顿儿童医院医疗中心接受手术的132名儿童群体中，对小脑胶质瘤的组织学组成的时间变化进行了检查。针对临床特征、组织学特征和肿瘤类型，研究了随时间的线性趋势。我们发现在41年的研究期间，胶质瘤A及其相关特征的发生率有增加的证据。这种肿瘤类型预后良好，在组织学上定义明确。胶质瘤B是一种预后不良的肿瘤类型，在时间方面相对稳定，因此与胶质瘤A明显不同。少突胶质细胞灶是胶质瘤A的一个特征，在相对较短的时间跨度内按手术年份聚集。该特征的生存率和男性比例与所研究的其他组织学特征有很大不同。
