Winston K, Gilles F H, Leviton A, Fulchiero A
J Natl Cancer Inst. 1977 Apr;58(4):833-8. doi: 10.1093/jnci/58.4.833.
We studied the relationship of histologic features to survival in a population of 132 children with cerebellar gliomas (excluding medulloblastomas). These children had their initial tumor operation at The Children's Hospital Medical Center of Boston between 1l927 and 1968. A classification system that accentuates differences in survival was derived on the basis of clustering of histologic features and survival. This division was supported by the existence of differentially distributed symptoms and signs and by differences in resectability. The two major subgroups of cerebellar gliomas had different patterns of clinical characteristics. Cerebellar glioma A had any of the four histologic features of microcyst, leptomeningeal deposit, Rosenthal fiber, or focus of oligodendroglia; children with glioma A had a 10-year survival rate of 94%. Glioma B, encompassing the histologic features of perivascular pseudorosette, high cell density, necrosis, mitosis, and calcification, was clearly defined but histologically less uniform; children with glioma B had a 10-year survival rate of 29%. These two groups accounted for 90% of the cerebellar gliomas in childhood.
我们研究了132例小脑胶质瘤（不包括髓母细胞瘤）患儿的组织学特征与生存率之间的关系。这些患儿于1927年至1968年间在波士顿儿童医院医学中心接受了首次肿瘤手术。基于组织学特征和生存率的聚类分析，得出了一个突出生存率差异的分类系统。这种分类得到了不同分布的症状和体征的存在以及可切除性差异的支持。小脑胶质瘤的两个主要亚组具有不同的临床特征模式。小脑胶质瘤A具有微囊肿、软脑膜沉积、罗森塔尔纤维或少突胶质细胞灶这四种组织学特征中的任何一种；患有胶质瘤A的儿童10年生存率为94%。胶质瘤B包括血管周围假菊形团、高细胞密度、坏死、有丝分裂和钙化等组织学特征，定义明确但组织学上不太一致；患有胶质瘤B的儿童10年生存率为29%。这两组占儿童期小脑胶质瘤的90%。
