19-氧代雄甾-4-烯-3,17-二酮增强醛固酮的作用。

19-Oxoandrost-4-ene-3,17-dione amplifies the action of aldosterone.

作者信息

Sekihara H, Yazaki Y

机构信息

Third Department of Internal Medicine, University of Tokyo, Faculty of Medicine, Japan.

出版信息

J Steroid Biochem Mol Biol. 1993 Jul;46(1):69-72. doi: 10.1016/0960-0760(93)90210-n.

DOI:10.1016/0960-0760(93)90210-n

PMID:8338792

Abstract

The amplification of the action of aldosterone by 19-oxoandrost-4-ene-3,17-dione (19-oxo-A-dione) was evaluated by mineralocorticoid bioassays using adrenalectomized rats. Pretreatment of rats with 19-oxo-A-dione did not cause any significant change in urinary Na/K ratio. However, aldosterone caused a significantly lower urinary Na/K ratio and Na excretion in rats pretreated with 19-oxo-A-dione than in rats without pretreatment. These results indicate that the sodium-retaining action of aldosterone is amplified by pretreatment with 19-oxo-A-dione.

摘要

通过对肾上腺切除大鼠进行盐皮质激素生物测定，评估了19-氧代雄甾-4-烯-3,17-二酮（19-氧代-A-二酮）对醛固酮作用的增强效果。用19-氧代-A-二酮预处理大鼠，其尿钠/钾比值未发生任何显著变化。然而，与未预处理的大鼠相比，醛固酮使经19-氧代-A-二酮预处理的大鼠尿钠/钾比值和钠排泄量显著降低。这些结果表明，用19-氧代-A-二酮预处理可增强醛固酮的保钠作用。