Agosti V, Stewart J W, Quitkin F M, Ocepek-Welikson K
Department of Psychiatry, Columbia University, New York, NY.
Compr Psychiatry. 1993 May-Jun;34(3):182-6. doi: 10.1016/0010-440x(93)90045-6.
Symptom Check List-90 (SCL-90) scores of 318 moderately depressed, nonmelancholic outpatients treated with phenelzine, imipramine, or placebo were compared with scores obtained from a demographically matched control group of 69 "normal" subjects. Pretreatment scores of depressed patients were significantly higher than those of the control group; after 6 weeks of treatment, they were indistinguishable from scores of the control group. These results suggest that symptoms of moderately depressed patients who benefit from treatment not only decrease from baseline, but are reduced to a level of symptomatology that is psychiatrically normal.
对318名使用苯乙肼、丙咪嗪或安慰剂治疗的中度抑郁、非忧郁门诊患者的症状自评量表90（SCL - 90）得分，与来自69名“正常”受试者的人口统计学匹配对照组的得分进行了比较。抑郁患者的治疗前得分显著高于对照组；治疗6周后，他们的得分与对照组的得分没有区别。这些结果表明，从治疗中获益的中度抑郁患者的症状不仅从基线水平下降，而且降至精神层面正常的症状水平。
