Teicher M H, Glod C A, Harper D, Magnus E, Brasher C, Wren F, Pahlavan K
Department of Psychiatry, Harvard Medical School, Belmont, MA.
J Am Acad Child Adolesc Psychiatry. 1993 Jul;32(4):760-9. doi: 10.1097/00004583-199307000-00009.
To determine whether circadian activity rhythms were altered in pediatric patients with depression. Evidence was sought for a shift in the timing of the rhythm, blunting of circadian amplitude, or emergence of noncircadian periodicities.
Locomotor activity was quantified in 57 patients with major depressive mood disorders (mean age 12.4 years) and 16 normal controls (9.9 years). Activity was measured in 5-minute epochs during 72 hours using belt-worn electronic activity monitors.
Patients with mood disorders displayed a 15% decrease in the amplitude of their circadian rhythm, and a 52% increase in the magnitude of their twice-daily (hemicircadian) rhythm. No significant difference emerged in the timing of the circadian rhythm. Depressed inpatients and outpatients displayed comparable disturbances, which were most marked in adolescents.
Circadian activity rhythms were dysregulated in pediatric patients with major depression. These findings may have etiological and diagnostic significance.
确定抑郁症患儿的昼夜活动节律是否发生改变。寻找节律时间偏移、昼夜振幅减弱或非昼夜周期性出现的证据。
对57例重度抑郁情绪障碍患者（平均年龄12.4岁）和16名正常对照者（9.9岁）的运动活动进行量化。使用佩戴在腰部的电子活动监测器，在72小时内以5分钟为一个时间段测量活动。
情绪障碍患者的昼夜节律振幅下降了15%，每日两次（半昼夜）节律的幅度增加了52%。昼夜节律的时间没有显著差异。抑郁的住院患者和门诊患者表现出类似的紊乱，在青少年中最为明显。
重度抑郁症患儿的昼夜活动节律失调。这些发现可能具有病因学和诊断学意义。
