Beatty W W
Department of Psychiatry and Behavioral Sciences, University of Oklahoma Health Sciences Center, Oklahoma City 73104.
J Neurol Sci. 1993 Apr;115 Suppl:S38-41. doi: 10.1016/0022-510x(93)90207-f.
The characteristics of memory disturbance in multiple sclerosis (MS) are briefly reviewed and the interactions of conceptual and memory dysfunction in MS are considered. Although conceptual functions such as abstraction and problem solving traditionally have been considered to be frontal lobe functions, there is now convincing evidence from studies of patients with focal brain lesions that these capacities are not localized to the frontal lobes. Thus, the concept of frontal lobe dysfunction in MS is without empirical support. Nevertheless, studies examining the relationship between memory and conceptual impairment in MS have value for both basic and clinical neuroscience.
本文简要回顾了多发性硬化症（MS）中记忆障碍的特征，并探讨了MS中概念功能与记忆功能障碍之间的相互作用。虽然诸如抽象和解决问题等概念功能传统上被认为是额叶功能，但目前来自局灶性脑损伤患者研究的令人信服的证据表明，这些能力并非局限于额叶。因此，MS中额叶功能障碍的概念缺乏实证支持。尽管如此，研究MS中记忆与概念损伤之间的关系对基础神经科学和临床神经科学均具有价值。
