Secrist J A, Comber R N, Gray R J, Gilroy R B, Montgomery J A
Organic Chemistry Department, Southern Research Institute, Birmingham, Alabama 35255-5305.
J Med Chem. 1993 Jul 23;36(15):2102-6. doi: 10.1021/jm00067a008.
Various 5'-substituted derivatives (2, 3, 6a, 6b, 9a, 9b, 12, 13b, and 15) of carbocyclic 3-deazaadenosine (3-deaza CAdo, 1) were prepared from 3-deaza CAdo (1) and evaluated as antiviral agents against a number of viruses, including HIV-1. Several of the compounds had moderate to good antiviral activity against vaccinia (VV) and vesicular stomatitis (VSV) viruses; however, the antiviral activity of the analogues did not exceed that of the parent compound. No anti-HIV activity was detected.
