肌酐、肌醇和甲基胍对腺嘌呤诱导的大鼠慢性肾衰竭肾脏影响的比较。

Comparison of renal effects of creatinine, creatol and methylguanidine in rats with adenine-induced chronic renal failure.

作者信息

Yokozawa T, Oura H, Ienaga K, Nakamura K

机构信息

Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.

出版信息

Nephron. 1993;64(3):424-8. doi: 10.1159/000187365.

DOI:10.1159/000187365

PMID:8341388

Abstract

Creatinine (Cr), creatol and methylguanidine (MG), which accumulate in the body with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 20 days to induce renal failure. Then each of the test substances was administered intraperitoneally, and renal function of the rats was determined. The changes in glomerular filtration rate, renal plasma flow and renal blood flow after administration of Cr were only slight in comparison with those of the control group. Creatol or MG administration induced a significant decrease in renal function. In addition, the level of MG in serum, liver and kidney was extraordinarily high in rats given creatol or MG. The toxic effects are discussed on the basis of these results.

摘要

肌酐（Cr）、肌醇和甲基胍（MG）在给予腺嘌呤后会随着肾衰竭的进展在体内蓄积，为比较它们的毒性，将它们分别给予大鼠。给大鼠喂食含腺嘌呤的食物20天以诱导肾衰竭。然后将每种受试物质腹腔注射，并测定大鼠的肾功能。与对照组相比，注射Cr后肾小球滤过率、肾血浆流量和肾血流量的变化很小。注射肌醇或MG会导致肾功能显著下降。此外，给予肌醇或MG的大鼠血清、肝脏和肾脏中的MG水平异常高。基于这些结果对毒性作用进行了讨论。