Yokozawa T, Mo Z L, Oura H
Department of Applied Biochemistry, Toyama Medical and Pharmaceutical University, Japan.
Nephron. 1989;51(3):388-92. doi: 10.1159/000185328.
Methylguanidine (MG), guanidinosuccinic acid (GSA) and creatinine (Cr), which accumulate in the body in parallel with the progress of renal failure after adenine administration, were given separately to rats in order to compare their toxicities. Food containing adenine was given to rats for 24 days to induce renal failure, and then each of the test substances was administered intraperitoneally from the following day, the survival rates of the rats being subsequently determined. Administration of MG at varying doses produced a dose-dependent decrease in the survival rate, whereas the survival curves obtained for rats given GSA or Cr indicated weak toxicity. The levels of MG, GSA or Cr accumulated in the body were extraordinarily high in surviving rats after 14 days of administration of each respective compound. The toxic effects are discussed on the basis of these results.
在给予腺嘌呤后，随着肾衰竭的进展在体内平行蓄积的甲基胍（MG）、胍基琥珀酸（GSA）和肌酐（Cr），被分别给予大鼠以比较它们的毒性。给大鼠喂食含腺嘌呤的食物24天以诱导肾衰竭，然后从次日起腹腔注射每种受试物质，随后测定大鼠的存活率。不同剂量的MG给药导致存活率呈剂量依赖性下降，而给予GSA或Cr的大鼠所获得的存活曲线显示毒性较弱。在分别给予每种化合物14天后，存活大鼠体内蓄积的MG、GSA或Cr水平极高。基于这些结果对毒性作用进行了讨论。
