Yokozawa T, Fujitsuka N, Oura H
Department of Applied Biochemistry, Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University, Japan.
Nephron. 1991;58(1):90-4. doi: 10.1159/000186384.
Each of creatinine (Cr), guanidinoacetic acid (GAA) and arginine (Arg) was administered intraperitoneally to rats with renal failure, and the levels of methylguanidine (MG) in the serum, liver, kidney, muscle and urine were determined at certain intervals. The levels of MG in the serum, liver, kidney, muscle and urine after Cr administration increased markedly with time. The amount of total MG at 24 h was estimated to be 114 micrograms/100 g body weight, which accounted for 0.46% of the Cr dose. In contrast, changes in MG levels after administration of GAA or Arg were only slight in comparison with those after Cr administration. Thus, MG was proved to be produced mainly from Cr.
将肌酐（Cr）、胍基乙酸（GAA）和精氨酸（Arg）分别腹腔注射给肾衰竭大鼠，并在一定时间间隔测定血清、肝脏、肾脏、肌肉和尿液中的甲基胍（MG）水平。注射Cr后，血清、肝脏、肾脏、肌肉和尿液中的MG水平随时间显著升高。24小时时总MG量估计为114微克/100克体重，占Cr剂量的0.46%。相比之下，注射GAA或Arg后MG水平的变化与注射Cr后的变化相比仅为轻微。因此，证明MG主要由Cr产生。
